Steiner R, et al. ACER-001: A Potential Alternative to Sodium and Glycerol Phenylbutyrate for Treatment of Urea Cycle Disorders. GMDI May 2022.
Cederbaum S, et al. Taste-Masked Coating of Sodium Phenylbutyrate (ACER-001) Improves the Palatability of Sodium Phenylbutyrate for Treatment of Urea Cycle Disorders. GMDI May 2022.
Steiner R, et al. The Pharmacokinetics of Taste-Masked Sodium Phenylbutyrate (ACER-001) for the Treatment of Urea Cycle Disorders Under Fasting and Fed Conditions in Healthy Volunteers. SIMD April 2022.
Cedarbaum S, et al. Taste-Masked Coating of Sodium Phenylbutyrate (ACER-001) Improves the Palatability of Sodium Phenylbutyrate for Treatment of Urea Cycle Disorders. SIMD April 2022.
Osaka S, et al. A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate in healthy volunteers. Mol Genetics and Metab. Feb. 2021.
Nakano S, et al. Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis. Sci Rep 9, 17075 (2019).
Shchelochkov et al. Barriers to drug adherence in the treatment of urea cycle disorders: Assessment of patient, caregiver, and provider perspectives.
Zubarioglu et al. Impact of sodium phenylbutyrate treatment in acute management of maple syrup urine disease attacks: a single-center experience (2020).
Brunetti-Pierri et al. Phenylbutyrate therapy for maple syrup urine disease. Hum Mol Genet. 2011 February 15; 20(4): 631–640
Moon, Z. et al. J Factors related to the experience of menopausal symptoms in women prescribed tamoxifen. Journal of Psychosomatic Obstetrics & Gynecology, 2017 Vol. 38, No. 3, 226–235
Prague J., et al. Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action. Menopause. 2018 Aug;25(8):862-869
Challapalli, A, et al. Evaluating the prevalence and predictive factors of vasomotor and psychological symptoms…Clin. and Transl. Radiation Onc. 10 (2018) 29–35
Herman Depypere et al., ENDO2017
Baderkhan, H, et al. Celiprolol Treatment in Patients with vEDS. Euro Journal of Vascular and Endovascular Surgery. Nov. 2020 (Swedish Patient Registry Data)
Poster: Academy of Managed Care Pharmacy Nexus 2019 Tetali et al October 2019
Abstract: Journal of Managed Care & Specialty Pharmacy
Pilot Study to Estimate the Healthcare Cost Associated with Clinical Events in Vascular Ehlers-Danlos Syndrome
Society for Vascular Medicine 2019 Annual Scientific Sessions Tetali et al May 2019
Pilot Study to Evaluate Effect of Antihypertensive Therapy on the Rates of Clinical Events in Patients with Vascular Ehlers-Danlos Syndrome
Journal of the American College of Cardiology 2019; 73:194857 Frank Peer Reviewed Publication
Audio summary by Editor-in-Chief of JACC, Dr. Valentin Fuster
Vascular Ehlers-Danlos Syndrome: Publication
Vascular Ehlers-Danlos Syndrome: Long-Term Observational Study
Lancet 2010; 376: 1476-84 Ong Peer Reviewed Publication
Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial
NORD Poster Presentation Grabowsky October 2018
Big Data Analytics to Estimate Prevalence of Ehlers-Danlos Syndrome(Vascular Phenotype) and Rate of Rupture Events
Survival is affected by mutation type and molecular mechanism in vascular EhlersDanlos syndrome (EDS type IV)
Celiprolol but not losartan improves the biomechanical integrity of the aorta in a mouse model of vascular Ehlers Danlos syndrome
Sun J, et al. Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications. Nature May 2020.
Bojkova D, et al. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Nature 2020.
Ianevski A, et al. Antiviral options against SARS-CoV-2 infection. May 2020.
Yang S, et al. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.
Andersen, P.I., et al. Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine. Viruses 2019, 11, 964.
Del Puerto et al. Pren. méd. argent., 55: 818, 1968
Annamalai et al. Emetine Hydrochloride in the Treatment of Herpes Zoster. 1968
Shen L, et al. High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses. J Virol. 2019 May 29;93(12).
Choy et al. Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 Jun; 178: 104786